Closer to a Cure for Cystic Fibrosis Essays -- Proteasomes Cystic Fibr

Overcoming Proteasomes One Step Closer to a bring to for Cystic FibrosisTake a deep breath and consider how lightsome it was to do so. Now picture struggling andgasping for air everyday normal, wakeful tasks to the average person prove to be quite challengingto a patient of cystic fibrosis. Scientists have always been daunted by this black ingredienttic diseasethat affects the body by excreting a heavy mucus in the lungs, making breathing difficult andblocking the ducts leading(a) from the pancreas, causing poor digestion of food (1). Untilrecently, there was nothing that scientists could do to tender a long-term cure, but even thoughscientists cannot cure patients unrivaled hundred percent, they can increase their life expectancy.Despite having discovered the cystic fibrosis genes location in 1989, numerous underlyingobstacles delay complete success (2). The primary obstacle that prevents scientists frommaking gene therapy an rough-and-ready cure is the placement of the healthy genes into long-term cells,the cells that remain long affluent to be replicated. The replacement of the healthy gene intolong-term cells is necessary because these cells be the new cells, thereby distributing thehealthy DNA throughout the body. The properly carrying into action gene is attached to a vector orcarrying molecule that entrust transport the therapeutic gene to the patients target cells (2).Currently, the well-nigh common vector is a virus because it can easily take prisoner the gene and deliver itinto the cell the virus infiltrates the corrupt cells and places the healthy gene into the nucleuswhich then transforms the corrupt cell into one which operates properly (2). The lone(prenominal) difficultyis that the bodys natural immune system provides many another(prenominal) b... ...t-education/tips/ccysfibr.html.2. Institute NHGR. Gene Therapy Internet. 2007 2007 September 18 Available from.3. Stefano Ferrari DMG, Eric WFW Alton. Barriers to and new approac hes for gene therapyand gene delivery in cystic fibrosis. Advanced Drug Delivery Reviews 200264 1373-1393.4. J Kim C-PC, KG Rice. The proteasome metabolizes peptide-mediated nonviral genedelivery systems. Gene Therapy 2006 12 1681-1690.5. Neil Campbell, and Lawrence Mitchell (1999). Biology. rude(a) York, Addison WesleyLongman, Inc.6. Institute NHGR. Learning About Cystic Fibrosis Internet. 2007 2007 September 18Available from .7. U Griesenbach DG, and EWFW alton. Gene therapy progress and prospects cysticfibrosis. Gene Therapy 2007 13 1071-1077.